FARAD Partnership with PhAST

FARAD is pleased to announce the formation of a collaborative partnership with the Pharmacology Analytical Support Team (PhAST) program at Iowa State University College of Veterinary Medicine. The primary mission of the PhAST program is to provide rapid analyses for drugs, toxins and biomarkers in organic matrices with a major aim of helping livestock producers improve the health and welfare of livestock as well as safeguarding international trade agreements and public health. The PhAST team is composed of veterinary clinical pharmacologists and toxicologists that are supported by analytical chemists. The group is centered around a laboratory facility with a focus on high throughput analyses intended to quantify exogenous and endogenous compounds in a wide array of organic matrices, including products derived from food-production animals. PhAST also provides analytical services in support of multi-sample analyses, quantitative determination of known analytes as well as pharmacological and toxicological research for academic, industry, and government entities.

Drug Screening in Milk
The milk drug screening panel offered by PhAST covers 41 drugs, including antibiotics, NSAID's, antihistamines, a beta-agonist (ractopamine) and several anthelmintic drugs. Drug residues are measured by liquid chromatography-mass spectrometry (LC-MS/MS). Multiple chemical classes of antimicrobial agents are determined in the screening assay panel, including beta-lactams (4), cephalosporins (2), tetracyclines (4), sulfonamides (8), macrolides (4), lincosamides (2) and phenicols (2). In addition, several other therapeutic agents are assayed, including flunixin, a flunixin metabolite, meloxicam, tripelennamine and ractopamine. The drug panel also includes anthelmintic drugs such as thiabenzadole and three macrocyclic lactones (e.g. ivermectin). The assay is sensitive to 1 ppb (ng/g) for the majority of drugs in the screening panel with a limit of quantitation (LOQ) of 0.5 ng/g for most of the drugs and 0.1 ng/g for drugs such as flunixin, meloxicam, ractopamine, and tripelennamine. Estimated turnaround time is three days from sample receipt.

Link to the PhAST form in PDF to view/download the PhAST Lab Antibiotic-Antimicrobial Milk Form (in PDF).