Prohibited Drug List:
Diethylstilbestrol (DES)
Chloramphenicol
Nitroimidazoles (including dimetridazole, metronidazole and ipronidazole)
Sulfonamide use in adult dairy cattle*
Clenbuterol
Dipyrone**
The fluoroquinolones (examples enrofloxacin and danofloxacin)
The glycopeptides (example vancomycin)
Nitrofurans (including nitrofurazone, furazolidone, topical use
prohibited as well)
Phenylbutazone use in adult dairy cattle*
Gentian Violet
*Lactating (adult) dairy cattle are defined by FDA as dairy cattle
20 months of age or older regardless of whether they are milking
or dry. Currently the only sulfonamide available for use in dairy
cattle older than 20 months of age is sulfadimethoxine (SDM).
In adult dairy cattle this drug may only be used on-label. Administering
higher doses or sustained release SDM products is prohibited.
Aside from the above AMDUCA list, regulations related to the Pasteurized
Milk Ordinance (PMO) prohibit the presence of dimethyl sulfoxide
(DMSO) and colloidal silver on dairies.
** Because dipyrone-containing products are not available for
either humans or animals, it is not typically included on lists
of extralabel prohibitions published by CVM. Old stockpiles of
the drug, however, do occasionally surface. Any use of dipyrone
in food animals remains a violation of the Food Drug and Cosmetic
Act.
PHENYLBUTAZONE ADDED TO PROHIBITED LIST
Effective May 29, 2003 the Food and Drug Administration (FDA) will
prohibit extralabel use of phenylbutazone animal and human drugs
in female dairy cattle 20 months of age or older. The FDA is issuing
the order based on evidence that extralabel use of phenylbutazone
in female dairy cattle 20 months of age or older will likely cause
an adverse event in humans. With this action the use of any phenylbutazone
in an adult dairy cow becomes a violation of the Food Drug and Cosmetic
Act and one of FDA's highest regulatory priorities. The FDA invites
written or electronic comments on the order until April 29, 2003.
The entire text of the order of prohibition can be viewed at:
http://www.fda.gov/OHRMS/DOCKETS/98fr/03-4741.htm.