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Withdrawal Interval (WDI) Recommendations

for cattle, taken from the FARAD Digests

WARNING!

Extra Label Use of this drug is permissible under AMDUCA only if such use is by or on the lawful written or oral order of a licensed veterinarian within the context of a valid veterinarian-client-patient relationship.


Below are the WDI recommendations for the various route and dosage combination(s) for extra-label administration of in cattle.

 

Drug Route
Abbreviations (EPI) Epidural
(IM) Intramuscular
(IMM) Intramammary
(INF) Infiltration
(IU) Intrauterine
(IV) Intravenous
(PO) Oral
(SC) Subcutaneous
(TOP) Topical
Dosage Frequency Meat WDI Milk WDI
acepromazine IM up to 0.44mg/kg single and multiple doses 7 days 48 hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
acepromazine
acepromazine IV up to 0.13 mg/kg single and multiple doses 7 days 48 hours
acepromazine Reference(s): Extralabel use of tranquilizers and general anesthetics
activated charcoal PO n.a. n.a. 0 days 0 days
activated charcoal Reference(s): Antidotes in food animal practice
atropine IV up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine IM up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
atropine
atropine SC up to 0.2 mg/kg every 4-6 hours 28 days 6 days
atropine
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
atropine Reference(s): Antidotes in food animal practice
detomidine IV up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
detomidine
detomidine IM up to 0.08 mg/kg single and multiple doses 3 days 72 hours
detomidine Reference(s): Extralabel use of tranquilizers and general anesthetics
dimethyl sulfoxide (DMSO) TOP n.a. n.a. 4 days 96 hours
dimethyl sulfoxide (DMSO)
Warnings:
pharmaceutical grade DMSO only
dimethyl sulfoxide (DMSO) Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides
epinephrine IV n.a. multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine IM n.a. multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
epinephrine
epinephrine SC n.a. multiple doses 0 days 0 days
epinephrine
Warnings:
endogenous substance with rapid metabolism
epinephrine Reference(s): Antidotes in food animal practice
florfenicol IMM 20 mg/kg single dose 28 days 120 hours and test with Charm II assay
florfenicol
Warnings:
systemic absorption post IMM infusion occurs
florfenicol Reference(s): Extralabel intramammary use of drugs in dairy cattle
flunixin meglumine IM 1.1 to 2.2 mg/kg single dose 10 days 96 hours
flunixin meglumine Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine
flunixin meglumine
flunixin meglumine IM 1.1 to 2.2 mg/kg multiple doses up to 60 days  
flunixin meglumine Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine
flunixin meglumine
flunixin meglumine IV 1.1 to 2.2 mg/kg single dose 7 days 84 hours
flunixin meglumine Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine
flunixin meglumine
flunixin meglumine PO 1.1 to 2.2 mg/kg single dose 10 days 96 hours
flunixin meglumine Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine
flunixin meglumine
flunixin meglumine PO 1.1 to 2.2 mg/kg multiple doses up to 60 days  
flunixin meglumine Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine
flunixin meglumine
flunixin meglumine SC 1.1 to 2.2 mg/kg single dose 10 days 96 hours
flunixin meglumine Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine
flunixin meglumine
flunixin meglumine SC 1.1 to 2.2 mg/kg multiple doses up to 60 days  
flunixin meglumine Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine
gentamicin IV up to 5 mg/kg every 24 hours for 10 days 18 months 5 days
gentamicin
Warnings:
test milk before returning to the milking string
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin IM up to 5 mg/kg every 24 hours for 10 days 18 months 5 days
gentamicin
Warnings:
test milk before returning to the milking string
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin SC up to 5 mg/kg every 24 hours for 10 days 18 months 5 days
gentamicin
Warnings:
test milk before returning to the milking string
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin IV n.a. n.a. 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin IM n.a. n.a. 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin SC n.a. n.a. 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin PO n.a. n.a. 18 months  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin TOP n.a. n.a. 1 day  
gentamicin Reference(s): Aminoglycoside residues in food of animal origin
gentamicin
gentamicin IMM 500 mg/quarter n.a. 180 days at least 10 days
gentamicin
Warnings:
FARAD strongly discourages intramammary administration of gentamicin in dairy cattle. Veterinarians are cautioned that the intramammary use of gentamicin is likely to be associated with prolonged tissue residues in cattle.
gentamicin Reference(s): Extralabel intramammary use of drugs in dairy cattle
guaifenesin IV up to 100 mg/kg single and multiple doses 3 days 48 hours
guaifenesin Reference(s): Extralabel use of tranquilizers and general anesthetics
ivermectin PO 0.2 mg/kg single dose 24 days 28 days
ivermectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
ivermectin
ivermectin SC 0.2 mg/kg single dose 35 days 47 days
ivermectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
ivermectin
ivermectin TOP 0.5 mg/kg single dose 48 days 53 days
ivermectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
ketamine IM up to 10 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine
ketamine IV up to 2 mg/kg single and multiple doses 3 days 48 hours
ketamine Reference(s): Extralabel use of tranquilizers and general anesthetics
ketamine
ketamine IV 5 mg/kg single and multiple doses Contact Farad 48 hours
ketamine Reference(s): Pharmacokinetics of ketamine in plasma and milk of mature Holstein cows
lidocaine w/epinephrine INF n.a. single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
lidocaine w/epinephrine
lidocaine w/epinephrine EPI n.a. single and multiple doses 1 day 24 hours
lidocaine w/epinephrine Reference(s): Extralabel use of tranquilizers and general anesthetics
oxytetracycline (long-acting) IM 20 - 40 mg/kg single dose 50 days  
oxytetracycline (long-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (long-acting)
oxytetracycline (long-acting) IV 20 - 30 mg/kg single dose 192 hours  
oxytetracycline (long-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (long-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (long-acting)
oxytetracycline (long-acting) IM 20 - 30 mg/kg single dose 192 hours  
oxytetracycline (long-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (long-acting) Reference(s): Extralabel use of oxytetracycline
moxidectin SC 0.2 mg/kg single dose 49 days Not Available
moxidectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
moxidectin
moxidectin TOP 0.5 mg/kg single dose 0 days 0 days
moxidectin Reference(s): Extralabel use of ivermectin and moxidectin in food animals
oxytetracycline IMM 426 mg every 12-24 hours for 1-3 doses 19 days 96 hours and test
oxytetracycline
Warnings:
diffuses into untreated quarters
oxytetracycline Reference(s): Extralabel use of oxytetracycline
oxytetracycline
oxytetracycline IMM 850 mg every 12-24 hours for 1-3 doses 19 days 120 hours and test
oxytetracycline
Warnings:
diffuses into untreated quarters
oxytetracycline Reference(s): Extralabel use of oxytetracycline
oxytetracycline
oxytetracycline IMM 500 mg/quarter n.a. 28 days 6 days
oxytetracycline
Warnings:
drug penetrates untreated quarters, therefore all milk should be discarded (not just treated quarter)
oxytetracycline Reference(s): Extralabel intramammary use of drugs in dairy cattle
oxytetracycline
oxytetracycline IU up to 2 g single dose 28 days 72 hours and test
oxytetracycline
Warnings:
only aqueous formulations of oxytetracycline and test as there is interindividual variability in residue elimination
oxytetracycline Reference(s): Update on FARAD food animal drug withholding recommendations
oxytetracycline
oxytetracycline IU 4 - 6 g single dose 35 days 192 hours and test
oxytetracycline Reference(s): Extralabel use of oxytetracycline
procaine penicillin g Warnings:
  • For other routes please contact FARAD.
procaine penicillin g
procaine penicillin g SCJ up to 300,000 units n.a. 12 days  
procaine penicillin g
Warnings:
Includes products containing procaine penicillin only, not products containing benzathine penicillin or a combination of procaine and benzathine penicillin.
procaine penicillin g Reference(s): Extralabel use of penicillin in food animals
procaine penicillin
procaine penicillin Warnings:
  • These WDI recommendations apply to meat and milk following extralabel administration of Crysticillin (NADA 065-174), or Pro-Pen-G, PenAqueous, VetriPenG, PenJect (NADA 065-505) products ONLY. The veterinarian is encouraged to contact FARAD for all other animal categories or formulations.
  • Do NOT use these recommendations for PPG products with NADA #064-010 (Norocillin, Agricillin, Bactracillin G, PenOne Pro, Aqua-Cillin, Penicillin G Procaine Injection); these products have different residue depletion profiles than the other procaine penicillin G products. The NADA number can be found on the bottle label.
  • PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin IM 24,000 units/kg once daily for 5 days 7 days 6 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
procaine penicillin
procaine penicillin IM 24,000 units/kg twice daily for 5 days 8 days 7 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
procaine penicillin
procaine penicillin IM 33,000 units/kg once daily for 5 days 8 days 7 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
procaine penicillin
procaine penicillin IM 33,000 units/kg twice daily for 5 days 9 days 8 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
procaine penicillin
procaine penicillin IM 44,000 units/kg once daily for 5 days 8 days 8 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
procaine penicillin
procaine penicillin IM 44,000 units/kg twice daily for 5 days 9 days 9 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
procaine penicillin
procaine penicillin IM 66,000 units/kg once daily for 5 days 10 days 9 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
procaine penicillin
procaine penicillin IM 66,000 units/kg twice daily for 5 days 11 days 10 days
procaine penicillin Warnings: This WDI applies to meat and milk following extralabel administration of Crysticillin, Pro-Pen-G products ONLY. The veterinarian is encouraged to contact FARAD for other animal categories or formulations. PPG suspension must be adequately shaken and mixed prior to use and injection volume must not exceed 10 mL at one site.
procaine penicillin Reference(s): Update on withdrawal intervals following extralabel use of procaine penicillin G in cattle and swine
povidone-iodine IMM n.a. n.a.   n.a.
povidone-iodine
Warnings:
for cessation of lactation, more effective than chlorhexidene, do not milk treated quarter
povidone-iodine Reference(s): Extralabel intramammary use of drugs in dairy cattle
pralidoxime (2-PAM) IM up to 30 mg/kg every 8 hours 28 days 6 days
pralidoxime (2-PAM)
Warnings:
treatment of organophosphate toxicosis; be sure there are no organophosphates residues
pralidoxime (2-PAM) Reference(s): Antidotes in food animal practice
oxytetracycline (short-acting) IV 10 - 20 mg/kg up to 4 doses   144 hours
oxytetracycline (short-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IM 10 - 20 mg/kg up to 4 doses   144 hours
oxytetracycline (short-acting)
Warnings:
also recommend testing due to variability
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IV greater than 20 mg/kg up to 4 doses every 24 hours 35 days  
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IM greater than 20 mg/kg up to 4 doses every 24 hours 35 days  
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting) IV 6.6 - 11 mg/kg intervals less than every 24 hours 28 to 30 days    
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
oxytetracycline (short-acting)
oxytetracycline (short-acting) IM 6.6 - 11 mg/kg intervals less than every 24 hours 28 to 30 days  
oxytetracycline (short-acting) Reference(s): Extralabel use of oxytetracycline
tetracyclines TOP n.a. n.a. 1 day 24 hours
tetracyclines
Warnings:
provided there is no oral ingestion
tetracyclines Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides
tolazoline IV 2 - 4 mg/kg single dose 8 days 48 hours
tolazoline Reference(s): Update on FARAD food animal drug withholding recommendations
vitamin K1 (phytonadione) IV 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) IM 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
vitamin K1 (phytonadione)
vitamin K1 (phytonadione) SC 0.5 - 2.5 mg/kg per label 0 days 0 days
vitamin K1 (phytonadione) Reference(s): Antidotes in food animal practice
xylazine IM 0.05 - 0.3 mg/kg single and multiple doses 4 days 24 hours
xylazine Reference(s): Update on FARAD food animal drug withholding recommendations
xylazine
xylazine IM 0.3 - 2.0 mg/kg single and multiple doses 10 days 120 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
xylazine
xylazine IV 0.016 - 0.1 mg/kg single and multiple doses 5 days 72 hours
xylazine Reference(s): Extralabel use of tranquilizers and general anesthetics
yohimbine IV up to 0.3 mg/kg single and multiple doses 7 days 72 hours
yohimbine Reference(s): Extralabel use of tranquilizers and general anesthetics
lidocaine Epidural up to 15 mL of 2% solution single and multiple doses 1 day 24 hours
lidocaine Reference(s): Pharmacokinetics of lidocaine in serum and milk of mature Holstein cows
lidocaine
lidocaine Infiltration up to 2 g in 100 mL single administration (inverted L block) 4 days 72 hours
lidocaine Reference(s): Pharmacokinetics of lidocaine in serum and milk of mature Holstein cows


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