Withdrawal Interval (WDI) Recommendations
for cattle, taken from the FARAD Digests
WARNING!
Extra Label Use of this drug is permissible under AMDUCA only if such use is by or on the lawful written or oral order of a licensed veterinarian within the context of a valid veterinarian-client-patient relationship.
Below are the WDI recommendations for the various route and dosage combination(s) for extra-label administration of in cattle.
| Drug | Route | Dosage | Frequency | Meat WDI | Milk WDI | |
|---|---|---|---|---|---|---|
| acepromazine | IM (Intramuscular) | up to 0.44mg/kg | single and multiple doses | 7 days | 48 hours | |
| acepromazine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| acepromazine | ||||||
| acepromazine | IV (Intravenous) | up to 0.13 mg/kg | single and multiple doses | 7 days | 48 hours | |
| acepromazine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| activated charcoal | PO (Oral) | not applicable | not applicable | 0 days | 0 days | |
| activated charcoal | Reference(s): Antidotes in food animal practice | |||||
| atropine | IV (Intravenous) | up to 0.2 mg/kg | every 4-6 hours | 28 days | 6 days | |
| atropine | Warnings:treatment of organophosphate toxicosis; be sure there are no organophosphates residues |
|||||
| atropine | Reference(s): Antidotes in food animal practice | |||||
| atropine | ||||||
| atropine | IM (Intramuscular) | up to 0.2 mg/kg | every 4-6 hours | 28 days | 6 days | |
| atropine | Warnings:treatment of organophosphate toxicosis; be sure there are no organophosphates residues |
|||||
| atropine | Reference(s): Antidotes in food animal practice | |||||
| atropine | ||||||
| atropine | SC (Subcutaneous) | up to 0.2 mg/kg | every 4-6 hours | 28 days | 6 days | |
| atropine | Warnings:treatment of organophosphate toxicosis; be sure there are no organophosphates residues |
|||||
| atropine | Reference(s): Antidotes in food animal practice | |||||
| detomidine | IV (Intravenous) | up to 0.08 mg/kg | single and multiple doses | 3 days | 72 hours | |
| detomidine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| detomidine | ||||||
| detomidine | IM (Intramuscular) | up to 0.08 mg/kg | single and multiple doses | 3 days | 72 hours | |
| detomidine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| dimethyl sulfoxide (DMSO) | Top (Topical) | not applicable | not applicable | 4 days | 96 hours | |
| dimethyl sulfoxide (DMSO) | Warnings:pharmaceutical grade DMSO only |
|||||
| dimethyl sulfoxide (DMSO) | Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides | |||||
| epinephrine | IV (Intravenous) | not applicable | multiple doses | 0 days | 0 days | |
| epinephrine | Warnings:endogenous substance with rapid metabolism |
|||||
| epinephrine | Reference(s): Antidotes in food animal practice | |||||
| epinephrine | ||||||
| epinephrine | IM (Intramuscular) | not applicable | multiple doses | 0 days | 0 days | |
| epinephrine | Warnings:endogenous substance with rapid metabolism |
|||||
| epinephrine | Reference(s): Antidotes in food animal practice | |||||
| epinephrine | ||||||
| epinephrine | SC (Subcutaneous) | not applicable | multiple doses | 0 days | 0 days | |
| epinephrine | Warnings:endogenous substance with rapid metabolism |
|||||
| epinephrine | Reference(s): Antidotes in food animal practice | |||||
| florfenicol | IMM (Intramammary) | 20 mg/kg | single dose | 28 days | 120 hours and test with Charm II assay | |
| florfenicol | Warnings:systemic absorption post IMM (Intramammary) (Intramammary) infusion occurs |
|||||
| florfenicol | Reference(s): Extralabel intramammary use of drugs in dairy cattle | |||||
| flunixin meglumine | IM (Intramuscular) | 1.1 to 2.2 mg/kg | single dose | 10 days | 96 hours | |
| flunixin meglumine | Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine | |||||
| flunixin meglumine | ||||||
| flunixin meglumine | IM (Intramuscular) | 1.1 to 2.2 mg/kg | multiple doses | up to 60 days | ||
| flunixin meglumine | Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine | |||||
| flunixin meglumine | ||||||
| flunixin meglumine | IV (Intravenous) | 1.1 to 2.2 mg/kg | single dose | 7 days | 84 hours | |
| flunixin meglumine | Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine | |||||
| flunixin meglumine | ||||||
| flunixin meglumine | PO (Oral) | 1.1 to 2.2 mg/kg | single dose | 10 days | 96 hours | |
| flunixin meglumine | Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine | |||||
| flunixin meglumine | ||||||
| flunixin meglumine | PO (Oral) | 1.1 to 2.2 mg/kg | multiple doses | up to 60 days | ||
| flunixin meglumine | Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine | |||||
| flunixin meglumine | ||||||
| flunixin meglumine | SC (Subcutaneous) | 1.1 to 2.2 mg/kg | single dose | 10 days | 96 hours | |
| flunixin meglumine | Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine | |||||
| flunixin meglumine | ||||||
| flunixin meglumine | SC (Subcutaneous) | 1.1 to 2.2 mg/kg | multiple doses | up to 60 days | ||
| flunixin meglumine | Reference(s): Avoiding violative flunixin meglumine residues in cattle and swine | |||||
| gentamicin | IV (Intravenous) | up to 5 mg/kg | every 24 hours for 10 days | 18 months | 5 days | |
| gentamicin | Warnings:test milk before returning to the milking string |
|||||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | ||||||
| gentamicin | IM (Intramuscular) | up to 5 mg/kg | every 24 hours for 10 days | 18 months | 5 days | |
| gentamicin | Warnings:test milk before returning to the milking string |
|||||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | ||||||
| gentamicin | SC (Subcutaneous) | up to 5 mg/kg | every 24 hours for 10 days | 18 months | 5 days | |
| gentamicin | Warnings:test milk before returning to the milking string |
|||||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | ||||||
| gentamicin | IV (Intravenous) | not applicable | not applicable | 18 months | ||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | IM (Intramuscular) | not applicable | not applicable | 18 months | ||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | ||||||
| gentamicin | SC (Subcutaneous) | not applicable | not applicable | 18 months | ||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | ||||||
| gentamicin | PO (Oral) | not applicable | not applicable | 18 months | ||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | ||||||
| gentamicin | Top (Topical) | not applicable | not applicable | 1 day | ||
| gentamicin | Reference(s): Aminoglycoside residues in food of animal origin | |||||
| gentamicin | ||||||
| gentamicin | IMM (Intramammary) | 500 mg/quarter | not applicable | 180 days | at least 10 days | |
| gentamicin | Warnings:FARAD strongly discourages intramammary administration of gentamicin in dairy cattle. Veterinarians are cautioned that the intramammary use of gentamicin is likely to be associated with prolonged tissue residues in cattle. |
|||||
| gentamicin | Reference(s): Extralabel intramammary use of drugs in dairy cattle | |||||
| guaifenesin | IV (Intravenous) | up to 100 mg/kg | single and multiple doses | 3 days | 48 hours | |
| guaifenesin | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| ivermectin | PO (Oral) | 0.2 mg/kg | single dose | 24 days | 28 days | |
| ivermectin | Reference(s): Extralabel use of ivermectin and moxidectin in food animals | |||||
| ivermectin | ||||||
| ivermectin | SC (Subcutaneous) | 0.2 mg/kg | single dose | 35 days | 47 days | |
| ivermectin | Reference(s): Extralabel use of ivermectin and moxidectin in food animals | |||||
| ivermectin | ||||||
| ivermectin | Top (Topical) | 0.5 mg/kg | single dose | 48 days | 53 days | |
| ivermectin | Reference(s): Extralabel use of ivermectin and moxidectin in food animals | |||||
| ketamine | IM (Intramuscular) | up to 10 mg/kg | single and multiple doses | 3 days | 48 hours | |
| ketamine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| ketamine | ||||||
| ketamine | IV (Intravenous) | up to 2 mg/kg | single and multiple doses | 3 days | 48 hours | |
| ketamine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| ketamine | ||||||
| ketamine | IV (Intravenous) | 5 mg/kg | single and multiple doses | Contact Farad | 48 hours | |
| ketamine | Reference(s): Pharmacokinetics of ketamine in plasma and milk of mature Holstein cows | |||||
| lidocaine w/epinephrine | Infiltration | not applicable | single and multiple doses | 1 day | 24 hours | |
| lidocaine w/epinephrine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| lidocaine w/epinephrine | ||||||
| lidocaine w/epinephrine | Epidural | not applicable | single and multiple doses | 1 day | 24 hours | |
| lidocaine w/epinephrine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| oxytetracycline (long-acting) | IM (Intramuscular) | 20 - 40 mg/kg | single dose | 50 days | ||
| oxytetracycline (long-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline (long-acting) | ||||||
| oxytetracycline (long-acting) | IV (Intravenous) | 20 - 30 mg/kg | single dose | 192 hours | ||
| oxytetracycline (long-acting) | Warnings:also recommend testing due to variability |
|||||
| oxytetracycline (long-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline (long-acting) | ||||||
| oxytetracycline (long-acting) | IM (Intramuscular) | 20 - 30 mg/kg | single dose | 192 hours | ||
| oxytetracycline (long-acting) | Warnings:also recommend testing due to variability |
|||||
| oxytetracycline (long-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| moxidectin | SC (Subcutaneous) | 0.2 mg/kg | single dose | 49 days | Not Available | |
| moxidectin | Reference(s): Extralabel use of ivermectin and moxidectin in food animals | |||||
| moxidectin | ||||||
| moxidectin | Top (Topical) | 0.5 mg/kg | single dose | 0 days | 0 days | |
| moxidectin | Reference(s): Extralabel use of ivermectin and moxidectin in food animals | |||||
| oxytetracycline | IMM (Intramammary) | 426 mg | every 12-24 hours for 1-3 doses | 19 days | 96 hours and test | |
| oxytetracycline | Warnings:diffuses into untreated quarters |
|||||
| oxytetracycline | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline | ||||||
| oxytetracycline | IMM (Intramammary) | 850 mg | every 12-24 hours for 1-3 doses | 19 days | 120 hours and test | |
| oxytetracycline | Warnings:diffuses into untreated quarters |
|||||
| oxytetracycline | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline | ||||||
| oxytetracycline | IMM (Intramammary) | 500 mg/quarter | not applicable | 28 days | 6 days | |
| oxytetracycline | Warnings:drug penetrates untreated quarters, therefore all milk should be discarded (not just treated quarter) |
|||||
| oxytetracycline | Reference(s): Extralabel intramammary use of drugs in dairy cattle | |||||
| oxytetracycline | ||||||
| oxytetracycline | IU (Intrauterine) | up to 2 g | single dose | 28 days | 72 hours and test | |
| oxytetracycline | Warnings:only aqueous formulations of oxytetracycline and test as there is interindividual variability in residue elimination |
|||||
| oxytetracycline | Reference(s): Update on FARAD food animal drug withholding recommendations | |||||
| oxytetracycline | ||||||
| oxytetracycline | IU (Intrauterine) | 4 - 6 g | single dose | 35 days | 192 hours and test | |
| oxytetracycline | Reference(s): Extralabel use of oxytetracycline | |||||
| procaine penicillin g | IU (Intrauterine) | up to 2 million units | not applicable | 14 days | ||
| procaine penicillin g | Warnings:for larger doses, test milk and urine before adding to bulk tank or slaughtering |
|||||
| procaine penicillin g | Reference(s): Extralabel use of penicillin in food animals | |||||
| procaine penicillin g | ||||||
| procaine penicillin g | Subconjunctival | up to 300,000 units | not applicable | 12 days | ||
| procaine penicillin g | Reference(s): Extralabel use of penicillin in food animals | |||||
| procaine penicillin g | ||||||
| procaine penicillin g | IM (Intramuscular) | 24,000 units/kg | every 24 hours for 5 days | 14 days | ||
| procaine penicillin g | Warnings:injection volume must not exceed 10 mls at one site |
|||||
| procaine penicillin g | Reference(s): Extralabel use of penicillin in food animals | |||||
| procaine penicillin g | ||||||
| procaine penicillin g | IM (Intramuscular) | 24,001 - 66,000 units/kg | every 24 hours for 5 days | 21 days | ||
| procaine penicillin g | Warnings:injection volume must not exceed 10 mls at one site |
|||||
| procaine penicillin g | Reference(s): Extralabel use of penicillin in food animals | |||||
| procaine penicillin g | ||||||
| procaine penicillin g | IM (Intramuscular) | up to 28,000 units/kg | every 24 hours for 5 days | 5 days | ||
| procaine penicillin g | Warnings:based on a study where injection volume did not exceed 20 mls |
|||||
| procaine penicillin g | Reference(s): Extralabel use of penicillin in food animals | |||||
| povidone-iodine | IMM (Intramammary) | not applicable | not applicable | not applicable | ||
| povidone-iodine | Warnings:for cessation of lactation, more effective than chlorhexidene, do not milk treated quarter |
|||||
| povidone-iodine | Reference(s): Extralabel intramammary use of drugs in dairy cattle | |||||
| pralidoxime (2-PAM) | IM (Intramuscular) | up to 30 mg/kg | every 8 hours | 28 days | 6 days | |
| pralidoxime (2-PAM) | Warnings:treatment of organophosphate toxicosis; be sure there are no organophosphates residues |
|||||
| pralidoxime (2-PAM) | Reference(s): Antidotes in food animal practice | |||||
| oxytetracycline (short-acting) | IV (Intravenous) | 10 - 20 mg/kg | up to 4 doses | 144 hours | ||
| oxytetracycline (short-acting) | Warnings:also recommend testing due to variability |
|||||
| oxytetracycline (short-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline (short-acting) | ||||||
| oxytetracycline (short-acting) | IM (Intramuscular) | 10 - 20 mg/kg | up to 4 doses | 144 hours | ||
| oxytetracycline (short-acting) | Warnings:also recommend testing due to variability |
|||||
| oxytetracycline (short-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline (short-acting) | ||||||
| oxytetracycline (short-acting) | IV (Intravenous) | greater than 20 mg/kg | up to 4 doses every 24 hours | 35 days | ||
| oxytetracycline (short-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline (short-acting) | oxytetracycline (short-acting) | IM (Intramuscular) | greater than 20 mg/kg | up to 4 doses every 24 hours | 35 days | |
| oxytetracycline (short-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline (short-acting) | IV (Intravenous) | 6.6 - 11 mg/kg | intervals less than every 24 hours | 28 to 30 days | ||
| oxytetracycline (short-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| oxytetracycline (short-acting) | ||||||
| oxytetracycline (short-acting) | IM (Intramuscular) | 6.6 - 11 mg/kg | intervals less than every 24 hours | 28 to 30 days | ||
| oxytetracycline (short-acting) | Reference(s): Extralabel use of oxytetracycline | |||||
| tetracyclines | Top (Topical) | not applicable | not applicable | 1 day | 24 hours | |
| tetracyclines | Warnings:provided there is no oral ingestion |
|||||
| tetracyclines | Reference(s): Residue avoidance after topical application of veterinary drugs and parasiticides | |||||
| tolazoline | IV (Intravenous) | 2 - 4 mg/kg | single dose | 8 days | 48 hours | |
| tolazoline | Reference(s): Update on FARAD food animal drug withholding recommendations | |||||
| vitamin K1 (phytonadione) | IV (Intravenous) | 0.5 - 2.5 mg/kg | per label | 0 days | 0 days | |
| vitamin K1 (phytonadione) | Reference(s): Antidotes in food animal practice | |||||
| vitamin K1 (phytonadione) | ||||||
| vitamin K1 (phytonadione) | IM (Intramuscular) | 0.5 - 2.5 mg/kg | per label | 0 days | 0 days | |
| vitamin K1 (phytonadione) | Reference(s): Antidotes in food animal practice | |||||
| vitamin K1 (phytonadione) | ||||||
| vitamin K1 (phytonadione) | SC (Subcutaneous) | 0.5 - 2.5 mg/kg | per label | 0 days | 0 days | |
| vitamin K1 (phytonadione) | Reference(s): Antidotes in food animal practice | |||||
| xylazine | IM (Intramuscular) | 0.05 - 0.3 mg/kg | single and multiple doses | 4 days | 24 hours | |
| xylazine | Reference(s): Update on FARAD food animal drug withholding recommendations | |||||
| xylazine | ||||||
| xylazine | IM (Intramuscular) | 0.3 - 2.0 mg/kg | single and multiple doses | 10 days | 120 hours | |
| xylazine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| xylazine | ||||||
| xylazine | IV (Intravenous) | 0.016 - 0.1 mg/kg | single and multiple doses | 5 days | 72 hours | |
| xylazine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| yohimbine | IV (Intravenous) | up to 0.3 mg/kg | single and multiple doses | 7 days | 72 hours | |
| yohimbine | Reference(s): Extralabel use of tranquilizers and general anesthetics | |||||
| lidocaine | Epidural | up to 15 mL of 2% solution | single and multiple doses | 1 day | 24 hours | |
| lidocaine | Reference(s): Pharmacokinetics of lidocaine in serum and milk of mature Holstein cows | |||||
| lidocaine | ||||||
| lidocaine | Infiltration | up to 2 g in 100 mL | single administration (inverted L block) | 4 days | 72 hours | |
| lidocaine | Reference(s): Pharmacokinetics of lidocaine in serum and milk of mature Holstein cows | |||||
If you have further questions or concerns, please contact our ELDU advice team.
